JASCO opens the door to the future of Circular Dichroism​
JASCO has produced the highest quality circular dichroism instrumentation for over 50 years. The J-1000 series is the result of many advances in technology combined with a great deal of customer input. These three new models are adaptable to meet any requirements and can be expanded as applications or budgets evolve.
The innovative optical system of the J-1700 allows the measurement of a CD spectrum in the near-IR region up to 2,500 nm using an unique Triple Detection system. JASCO J-1700 is ideal for structural analysis of metal complexes and colored proteins, magnetic CD spectra measurements of transition metals and CD measurements of the first and second overtones of vibrational transitions
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JASCO J-1500 allows the measurement of a CD spectrum in the vacuum UV region down to 163 nm. The vacuum UV region below 200 nm, is of critical importance for biomolecules, particularly in protein secondary structure estimation.
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High sensitivity combined with a maximum of 10,000 nm per minute scan speed allows the J-1700/J-1500 to measure samples quickly increasing productivity in your lab. An additional benefit is the minimal time exposure of biological samples to the high-energy UV light minimizing the risk of sample degradation.
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Stray light will result in distortion of the CD spectrum, particularly in the Far-UV region where the sample absorbance is high. The dual polarizing prism optical design equipped in the J-1000 Series results in stray light lower than 0.0003% enabling them to obtain high quality CD data even under conditions with high absorbance.
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The latest Quad Lock-in Amplifier allows the simultaneous acquisition of up to four data channels including CD, Absorbance, Linear Dichroism (LD), Fluorescence, Fluorescence detected CD (FDCD), Fluorescence detected LD (FDLD), Fluorescence Anisotropy and Optional Rotatory Dispersion (ORD).
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Designed as a “Chiroptical Spectroscopy Workbench” the J-1500 offers a wide range of accessories to allow it to be adapted to any application requirements. Temperature ramping, protein folding, enzyme kinetics, DNA/RNA interactions, natural organic chemistry, biochemistry, macromolecules and rapid scanning experiments are all possible.
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The J-1100 offers the basic cell holders for general CD/LD/Abs and Temperature control measurements.
Chiroptical spectroscopy has become one of the most important techniques for the characterization of biomolecules, determination of absolute configuration and stereochemical analysis. Since launching our first spectropolarimeter in 1961, JASCO has designed and built the finest in chiroptical instrumentation.
High-Throughput Circular Dichroism System (HTCD)
JASCO Circular Dichroism
Download related Application Notes, Article & Poster
JASCO Therapeutic Antibodies - Application eBook​
The market for therapeutic antibodies has been dramatically expanding over the past decades. Antibody drugs exhibit therapeutic effects, such as inhibiting the growth of malignant tumor cells and the activity of immune cells by binding antigens expressed in target cells with high affinity and specificity. Such antibody drugs are expected to be effective therapeutic agents for unmet medical needs.
The higher order structures (HOS) formed by therapeutic antibodies determines their efficacy. Because antibodies are unstable macromolecules, their HOS can be affected by various stimuli during the manufacturing process, resulting in reduced drug efficacy and impurities derived from the target substance. Therefore, HOS is considered to be a Critical Quality Attribute (CQA) and is subject to similarity studies, stability studies, and forced degradation studies in the R&D process from target assessment to lead optimization. In addition, it is monitored during the post-launch manufacturing process.
Antibody structures are hierarchically formed as primary, secondary, tertiary, and quaternary structures, and it is important to comprehensively evaluate each structure in the characterization of antibodies. This application eBook presents examples of evaluations using various analytical instruments, including Circular Dichrosim (CD) spectrometers, Fourier-transform infrared (FTIR) spectrometers, Raman imaging microscopes and High Performance Liquid Chromatography (HPLC).
JASCO Circular Dichroism
Watch JASCO Webinars
Basics of Protein Secondary Structure Analysis using FTIR and Circular Dichroism Spectroscopy
Orthogonal Similarity Assessment of Monoclonal Antibodies Using Circular Dichroism, FTIR and Raman
CD for Experimental Investigation & Verification of Protein Structure in the AlphaFold Era
Circular Dichroism - A Webinar on Sample Considerations and Parameter Optimization
To learn more about how JASCO's World leading chiroptical spectroscopy technology could assist in your research please contact us on freephone 0800 773 274 or email: info@specsci.nz