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J-1500 Circular Dichroism Spectrometer

J-1500

The new JASCO J-1500 is designed to meet the most demanding of CD applications. The performance level is unparalleled and the layout is suited for adaptation to a variety of different sampling methods. With CD, LD and Absorbance provided as standard the base unit is already very capable but when combined with optional measurement modes and sampling accessories in addition to the new Simultaneous Multi-Probe (SMP) acquisition system you can unleash the power only dreamed of by earlier systems  

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Features

VUV VUV

Benefit:

The Dual Polarizing Prism Monochromator is enhanced for performance into the Vacuum UV region with excellent stray-light rejection for accurate results.

NIR NIR

Benefit:

While the UV and Visible performance has been optimized the J-1500 can meet demands well into the NIR region. An optional PMT will extend the range to1250nm and a special detector and light source can be added to extend the range to 1600nm.

Measurement Modes Measurement Modes

Benefit:

The wide range of measurement modes available delivers a true chiroptical spectroscopy workbench. One spectrometer can measure CD, LD, Absorbance as standard. Optional modes include Fluorescence, Fluorescence Detected CD, Fluorescence Detected LD, Fluorescence Polarization/Anisotropy, Optical Rotatory Dispersion, Magnetic CD, Stopped flow CD/Abs/Fluorescence and more.

Simultaneous Multi-Probe (SMP) Simultaneous Multi-Probe (SMP)

Benefit:

The SMP technology delivers a new level of productivity that looks at your sample using several techniques at the same time to extract maximal information in minimal time.

Change Change

Benefit:

CD is easily monitored while altering conditions such as temperature, pH, solvent and buffer or binding and rapid kinetics to determine optimize long term stability or otherwise determine the dynamic properties of biomolecules.

High-Throughput High-Throughput

Benefit:

This auto-sampling CD system utilized 96 well micro-titor plates for completely unattended measurement of up to 192 samples. Samples are kept at a constant temperature while waiting for measurement which can include both spectral and temperature scanning. An adjustable wash cycle is performed between each sample which can be preserved and returned to the micro-plate for further analysis.

Microsampling Microsampling

Benefit:

You work hard for your samples and sometimes they are very limited. Amazing new accessories for the J-1000 allow you to measure excellent CD data from as little as a 5ul sample.

Validation Validation

Benefit:

Integrated Hg lamp for wavelength calibration and scale calibration material purity validated using NIST certified standards.

N2 N2

Benefit:

Computerized gas flow modeling was utilized to design the flow of the purge gas to optimize the flow efficiency to purge the fastest and most efficiently throughout the optical system without user intervention.

USB USB

Benefit:

Only a standard USB2 connection is made between the PC and the CD system assuring that future PC changes are easy to make without concern of compatibility specialized boards placed in the PC.

ISO ISO

Benefit:

Only JASCO CD systems are manufactured to the internationally recognized standards of the ISO quality program assuring you a product which consistently meets guaranteed specifications and a quality level that is defined and unsurpassed.

Applications

Advanced Application of CD Measurement for Pharmaceutical Research

Analyzing the interaction of human serum albumin and 3,5-diiodosalicylic acid

 

 
 
 
 
 
 
 
 
 
 
Human serum albumin (HSA) is the most abundant protein in blood plasma. HSA binds with pharmaceutical compounds and other in vivo substances, and plays an important role in the transport of these substances to target organs. Several studies have reported on the binding affinity of HSA and its interaction with various compounds 1)-3).

 

 

Please download the Advanced Application of CD Measurement for Pharmaceutical Research application note.

Software

Spectra Manager II Spectroscopy Software Suite

The new Jasco J-1000 Series utilizes the Spectra Manager II Spectroscopy Software Suite that is common with all other Jasco spectroscopy instrumentation. Spectra Manager II is a 64 bit program designed for Windows 7 and is a complete suite offering data acquisition, analysis and presentation in Canvas a publication quality printing and display module.

Optimized for multi-user environments Spectra Manager II can be very simple to operate but still offer the flexibility required for complex experiments. Measurement parameters are easy to store and retrieve for frequent measurements and a Macro command module allows automation of complex measurements including analysis and even printing to pre-set templates in the Canvas module.

User customizable toolbars are provided for frequently used functions. Analysis functions designed for CD data include integrated algorithms for Secondary Structure Analysis and conversion of various Optical Constant units. Thermal analysis functions include determination of Tm, enthalpy and entropy and a protein-ligand binding calculation program is available for use with the titration system.

Spectra Manager CFR is available for laboratories falling under the FDA mandate 21CFR11. The interface to the PC is simple a USB port allowing the PC to change easily in the future as new operating systems evolve.

Sample screen shots below:

Software Image 1

Software Image 2

Software Image 3

Accessories

Model Accessory Name
PTC-517 Single Cell Peltier Holder
MPTC-511 Automatic 6-Position In-Line Peltier Cell Changer
MPTC-513 Automatic 6-Position Turret Peltier Cell Changer
HTCD-1500 High-throughput CD System
FMO-522 Emission Monochromator
FDT-538 Emission Detector
EXPM-531 Extended Wavelength Detector to 1200nm (ExPMT)
EXIG-532 Extended Wavelength Detector to 1600nm (InGaAS)
ATS-530 Automatic Titration System
PML-534 FDCD Detector (PMT)
FDCD-550 FDCD Unit
FDCD-551 Artifact Free FDCD Unit
EXPML-535 Extended FDCD detector to 1200nm
EXIGL-536 Extended FDCD detector to 1600nm
CFC-574 LD/CD Couette flow cell
SFS-562 Two Syringe Stopped-Flow System
SFS-562T Two Syringe Stopped-Flow System with Temperature Control
SFS-563 Three Syringe Stopped-Flow System
SFS-563T Three Syringe Stopped-Flow System with Temperature Control
SFS-564 Four Syringe Stopped-Flow System
SFS-564T Four Syringe Stopped-Flow System with Temperature Control
HTC-572 Pressure-induced Ultra High-Temperature Measurement Cell
DRCD-574 Solid Sample Measurement Unit (BaSO 4 coating)
DRCD-575 Solid Sample Measurement Unit (Spectralon coating)
PM-491 1.6T Tesla Permanent Magnet MCD Unit
MCD-581 1.5 Tesla Variable Field Electromagnet
CRYS-582 Cryostat for solid samples
CRYL-583 Cryostat for liquid samples
SSCD-576 IR Style Sample Holder
ORDM-520 High Accuracy Optical Null ORD Unit
ORDE-521 Electrical Null ORD Unit